Collagen is often called the “structural protein” of the skin. It’s the key to keeping skin smooth, firm, and youthful-looking. However, as we age, collagen production naturally slows down, contributing to the formation of fine lines, wrinkles, and sagging skin. While many people turn to topical creams and treatments to boost collagen, an emerging supplement is being touted as a way to promote collagen production from the inside out: Nicotinamide Mononucleotide (NMN).
In this article, we’ll explore how NMN works in the body and why it’s increasingly becoming a go-to supplement for those looking to enhance skin health and collagen production. We’ll also look at the science behind NMN’s effects on skin aging, and why it’s gaining popularity among beauty and anti-aging enthusiasts.
What is Collagen and Why Does It Matter?
Collagen is the most abundant protein in the body, making up about 30% of your total protein content. It acts like a scaffolding for the skin, providing structure, elasticity, and hydration. In addition to the skin, collagen is found in the bones, muscles, tendons, and ligaments. In the skin, collagen is produced by fibroblasts, which are specialized cells that create and maintain the collagen fibers in the dermis (the middle layer of the skin).
As we age, collagen production begins to decline. This reduction in collagen is one of the main contributors to visible signs of aging, including:
- Wrinkles and fine lines: With less collagen, the skin loses its ability to remain firm and taut.
- Sagging skin: Collagen helps keep skin “plump” and firm, and without enough of it, skin can begin to sag, especially around areas like the jawline and cheeks.
- Dryness and thinning: Collagen also helps maintain the skin’s moisture retention, and without enough collagen, skin may become dry and thin.
This natural decline in collagen production typically starts around the age of 25, accelerating after the age of 40. This is why many people look for ways to stimulate collagen production as they age.
How NMN Influences Collagen Production
Nicotinamide Mononucleotide (NMN) is a molecule that serves as a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a vital coenzyme that powers various cellular processes, including energy production, DNA repair, and cellular maintenance. As we age, NAD+ levels decrease, leading to a decline in cellular health and regeneration, including the skin.
Here’s how NMN helps produce more collagen in the skin from the inside out:
1. Boosting NAD+ Levels
The most important mechanism by which NMN impacts collagen production is through its ability to increase NAD+ levels in the body. NAD+ is essential for a wide range of biological processes, including those that affect the skin. When NAD+ levels are replenished via NMN supplementation, it has several positive effects on skin health and collagen production:
- Enhanced Cellular Repair: NAD+ is involved in repairing DNA and other cellular damage, including damage to skin cells caused by environmental stressors like UV exposure and pollution. By supporting the repair of skin cells, NMN indirectly helps maintain healthy, youthful-looking skin.
- Cellular Energy Boost: NAD+ helps mitochondria, the “powerhouses” of the cell, produce ATP (adenosine triphosphate), which fuels all cellular processes. When skin cells have more energy, they can function more efficiently, including producing collagen more effectively.
2. Activation of Sirtuins
NAD+ also activates a group of proteins known as sirtuins. These proteins play a critical role in regulating longevity, cellular repair, and overall skin health. There are seven different sirtuins, but the most relevant for collagen production is SIRT1.
SIRT1 is known to:
- Regulate Skin Aging: SIRT1 helps control the expression of genes related to skin aging and the formation of wrinkles. It works by reducing inflammation and oxidative stress—two key factors in skin aging—and promoting skin cell survival.
- Stimulate Collagen Synthesis: Research has shown that sirtuins can increase the production of collagen in skin cells. They do this by activating pathways that stimulate the activity of fibroblasts, the cells responsible for producing collagen and other extracellular matrix components. By activating these pathways, NMN (via NAD+) helps stimulate collagen production from the inside out.
3. Protecting Against UV Damage
One of the biggest factors that accelerate collagen breakdown in the skin is sun exposure. Ultraviolet (UV) rays cause direct DNA damage and induce the production of harmful free radicals, both of which can degrade collagen. As we age, our ability to repair UV-induced damage decreases.
NMN helps support DNA repair mechanisms by boosting NAD+ levels, which in turn activates poly(ADP-ribose) polymerases (PARPs). PARPs are enzymes involved in the repair of DNA damage. They help counteract the effects of UV radiation by repairing the DNA in skin cells that have been harmed by sun exposure.
Furthermore, NAD+ and sirtuins also play a role in reducing oxidative stress in the skin, which helps protect against the damage caused by free radicals. This protection indirectly helps preserve collagen by minimizing the breakdown of collagen fibers that results from UV and environmental exposure.
4. Supporting Skin’s Structural Integrity
NMN’s ability to enhance NAD+ levels also plays a role in supporting the skin’s structural integrity. NAD+ is involved in the production of extracellular matrix (ECM) proteins, which include collagen and elastin. The ECM forms the foundation for the skin, providing it with strength, flexibility, and resilience.
Research suggests that by maintaining adequate levels of NAD+ through NMN supplementation, the body can better maintain the integrity of the ECM and prevent the degradation of collagen fibers. This means that the skin retains its youthful firmness and elasticity for longer.
5. Inhibiting Matrix Metalloproteinases (MMPs)
MMPs are enzymes that break down the extracellular matrix, including collagen. These enzymes are often activated by factors like oxidative stress and UV exposure, both of which contribute to premature aging of the skin.
Studies suggest that increased NAD+ levels help inhibit the activity of MMPs. This results in a slower breakdown of collagen, thereby helping to preserve skin structure and appearance.
Why NMN is Gaining Popularity for Skin Health
While there are many topical treatments for collagen production—such as retinoids, peptides, and vitamin C—NMN offers a unique, holistic approach to skincare by working from within. Here’s why more people are turning to NMN as a way to promote collagen and enhance skin health:
- Whole-body Anti-Aging Benefits: NMN doesn’t just focus on one aspect of skin health, but rather works to improve the overall function of the body. By boosting NAD+ levels, NMN promotes cellular repair, reduces inflammation, and increases energy—factors that contribute to glowing, youthful skin.
- Sustained, Long-term Results: While topical treatments can provide immediate results, the effects are often short-lived. NMN, on the other hand, works at the cellular level to enhance the body’s natural collagen production, providing sustained results over time.
- Non-Invasive: Unlike injectable treatments like dermal fillers or Botox, NMN provides a non-invasive solution to collagen production. It’s a natural way to support your skin’s health from the inside out, without the need for needles or surgeries.
- Scientific Backing: Research on NMN, particularly its role in NAD+ synthesis and its effects on aging, is rapidly expanding. As the science behind NMN continues to grow, more people are turning to it as a proven, science-backed supplement for anti-aging.
Conclusion
NMN is a powerful supplement that can boost collagen production in the skin by increasing NAD+ levels, activating sirtuins, protecting against UV damage, and supporting overall cellular health. By addressing the root causes of collagen depletion from the inside out, NMN offers a holistic approach to maintaining youthful, radiant skin. Whether you’re looking to reduce wrinkles, enhance skin elasticity, or simply support your skin’s structural integrity, NMN might be a valuable addition to your anti-aging regimen. As research continues, we’ll likely uncover even more exciting benefits of NMN for skin health and beyond. Learn more at
